GGTI-298 TFA - CAS# 1217457-86-7 60002 InChi: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4

InChi: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4

Formula: C17H20N6O4S

Tsisanova E

5-dihydro-1H-imidazol-2-yl)phenyl)urea)

https://en

GGTI-298 TFA - CAS# 1217457-86-7 60002 InChi: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4GGTI 298 TFA, CAS No. 1217457 86 7, is a potent geranylgeranyltransferase I (GGTase I) inhibitor with potential antitumor actrivity. GGTI 298 disrupts MAP kinase activation and G(1) S transition in Ki Ras overexpressing transformed adrenocortical cells. GGTI 298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin dependent kinase inhibitors. A potential mechanism for GGTI 298 antitumor activity. GGTI 298 arrests human tumor