RI-1 - CAS# 415713-60-9 n (1-7) Smiles: CC(C)CN(C[C@@H](O)[C@H](CC1C=CC=CC=1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12)S(=O)(=O)C1C=CC(N)=CC=1

Smiles: CC(C)CN(C[C@@H](O)[C@H](CC1C=CC=CC=1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12)S(=O)(=O)C1C=CC(N)=CC=1

4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1

also known as 10-DAB or 10-DAB III

also called doxorubicin

7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4

RI-1 - CAS# 415713-60-9 n (1-7) Smiles: CC(C)CN(C[C@@H](O)[C@H](CC1C=CC=CC=1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12)S(=O)(=O)C1C=CC(N)=CC=1RI 1 is an irreversible inhibitor of RAD51 (IC50s = 5 30 M), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI 1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI 1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into